Ontology highlight
ABSTRACT:
SUBMITTER: Hartman ZC
PROVIDER: S-EPMC2720025 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Hartman Zachary C ZC Appledorn Daniel M DM Serra Delila D Glass Oliver O Mendelson Todd B TB Clay Timothy M TM Amalfitano Andrea A
Virology 20080215 2
Human Adenovirus Type 4 (HAdV-4) is responsible for epidemic outbreaks of Acute Respiratory Disease (especially in military recruits), and is known to cause significant morbidity with several reported cases of mortality. However, we do not understand why this serotype causes such high morbidity, and have little insight into the immunobiology of HAdV-4 infections. We have now developed a replication attenuated HAdV-4 vector system, and through it, demonstrate that HAdV-4 virions have enhanced inf ...[more]