Novel adenovirus vectors 'capsid-displaying' a human complement inhibitor.
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ABSTRACT:
SUBMITTER: Seregin SS
PROVIDER: S-EPMC2895756 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Publications
Novel adenovirus vectors 'capsid-displaying' a human complement inhibitor.
Seregin Sergey S SS Hartman Zachary C ZC Appledorn Daniel M DM Godbehere Sarah S Jiang Haixiang H Frank Michael M MM Amalfitano Andrea A
Journal of innate immunity 20100211 4
Adenovirus (Ad) vectors are currently the most commonly utilized gene transfer vectors in humans worldwide. Unfortunately, upon contact with the circulatory system, Ads induce several, innate, complement-dependent toxicities that limit the full potential for Ad-based gene transfer applications. Therefore, we have constructed several novel Ad5-based vectors, 'capsid-displaying' as fiber or pIX fusion proteins, a complement-regulatory peptide (COMPinh). These novel Ads dramatically minimize Ad-dep ...[more]
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