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Stereoselective cross-coupling between allylic alcohols and aldimines.

ABSTRACT: A cross-coupling reaction between an allylic alcohol and an imine is described for stereoselective allylation of aromatic and aliphatic imines. This method provides operationally simple, enantioselective access to functionalized homoallylic amines. Particularly noteworthy is direct use of a functionalized allylic alcohol as an allylating reagent without prederivatization, which obviates the use of preformed organometallic reagents or activated imine derivatives.

SUBMITTER: Lysenko IL

PROVIDER: S-EPMC2720054 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature

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Stereoselective cross-coupling between allylic alcohols and aldimines.

Lysenko Ivan L IL Lee Hyung Goo HG Cha Jin Kun JK

Organic letters 20090701 14

A cross-coupling reaction between an allylic alcohol and an imine is described for stereoselective allylation of aromatic and aliphatic imines. This method provides operationally simple, enantioselective access to functionalized homoallylic amines. Particularly noteworthy is direct use of a functionalized allylic alcohol as an allylating reagent without prederivatization, which obviates the use of preformed organometallic reagents or activated imine derivatives. ...[more]

PMID: 19552387

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