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Complex allylation by the direct cross-coupling of imines with unactivated allylic alcohols.


ABSTRACT: Regioselective, stereoselective: The convergent coupling of allylic alcohols with imines to deliver stereodefined homoallylic amines is described (see scheme). The process proceeds with net allylic transposition without the intermediacy of allylic organometallic reagents. Two stereodefined centers and a geometrically defined di- or trisubstituted alkene are forged with high selectivity.

SUBMITTER: Takahashi M 

PROVIDER: S-EPMC3028933 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature

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Complex allylation by the direct cross-coupling of imines with unactivated allylic alcohols.

Takahashi Masayuki M   McLaughlin Martin M   Micalizio Glenn C GC  

Angewandte Chemie (International ed. in English) 20090101 20


Regioselective, stereoselective: The convergent coupling of allylic alcohols with imines to deliver stereodefined homoallylic amines is described (see scheme). The process proceeds with net allylic transposition without the intermediacy of allylic organometallic reagents. Two stereodefined centers and a geometrically defined di- or trisubstituted alkene are forged with high selectivity. ...[more]

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