Dataset Information

Cross-shift airway responses and long-term decline in FEV1 in cotton textile workers.

ABSTRACT:

Rationale

Acute airway response, measured as cross-shift change in FEV(1), to cotton dust may lead to subsequent chronic loss of lung function in exposed workers.

Objectives

To explore the association between the magnitude and frequency of cross-shift change and chronic loss of FEV(1).

Methods

Four hundred eight cotton workers and 417 silk workers from Shanghai textile mills were observed prospectively for 20 years, with cross-shift measurements at baseline and follow-up surveys at approximate 5-year intervals. To account for repeated measures of 5-year change, generalized estimating equations were used to estimate the relationship between the magnitude of cross-shift change in FEV(1) (DeltaFEV(1)) and subsequent 5-year annualized change. Linear regression models were used to examine the association between the number of drops in cross-shift FEV(1) (DeltaFEV(1) < 0) and annualized change over the entire study period.

Measurements and main results

Exposure to cotton dust was associated with a 10 ml/year decrement in 5-year annualized FEV(1) decline. In addition, every 10 ml in DeltaFEV(1) drop was associated with an additional 1.5 ml/year loss in annualized FEV(1) decline. The association between the frequency of drops and annualized decline was stronger for cotton workers than for silk workers over the entire study period.

Conclusions

Cotton workers had larger and more frequent drops, as well as excessive chronic declines in FEV(1), than did silk workers. The magnitude and frequency of cross-shift drops were associated with chronic loss in FEV(1) over the entire 20-year period examined.

SUBMITTER: Wang X

PROVIDER: S-EPMC2720104 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Cross-shift airway responses and long-term decline in FEV1 in cotton textile workers.

Wang Xiaorong X Zhang Hong-Xi HX Sun Bi-Xiong BX Dai He-Lian HL Hang Jin-Qing JQ Eisen Ellen E Su Li L Christiani David C DC

American journal of respiratory and critical care medicine 20071101 3

<h4>Rationale</h4>Acute airway response, measured as cross-shift change in FEV(1), to cotton dust may lead to subsequent chronic loss of lung function in exposed workers.<h4>Objectives</h4>To explore the association between the magnitude and frequency of cross-shift change and chronic loss of FEV(1).<h4>Methods</h4>Four hundred eight cotton workers and 417 silk workers from Shanghai textile mills were observed prospectively for 20 years, with cross-shift measurements at baseline and follow-up su ...[more]

PMID: 17975204

Similar Datasets

Project description:Few studies have investigated the significance of decreased FEV(1) in non-COPD, nonasthmatic healthy subjects. We hypothesized that a lower FEV(1) in these subjects is a potential marker of an increased susceptibility to obstructive lung disease such as asthma and COPD. This was a cross-sectional analysis of 1505 Japanese adults. We divided the population of healthy adults with no respiratory diseases whose FEV(1)/FVC ratio was ? 70% (n = 1369) into 2 groups according to their prebronchodilator FEV(1) (% predicted) measurements: < 80% (n = 217) and ? 80% (n = 1152). We compared clinical data - including gender, age, smoking habits, total IgE levels, and annual decline of FEV(1) - between these 2 groups. In addition, as our group recently found that TSLP variants are associated with asthma and reduced lung function, we assessed whether TSLP single nucleotide polymorphisms (SNPs) were associated with baseline lung function in non-COPD, nonasthmatic healthy subjects (n = 1368). Although about half of the subjects with lower FEV(1) had never smoked, smoking was the main risk factor for the decreased FEV(1) in non-COPD, nonasthmatic subjects. However, the subjects with lower FEV(1) had a significantly higher annual decline in FEV(1) independent of smoking status. Airflow obstruction was associated with increased levels of total serum IgE (P = 0.029) and with 2 functional TSLP SNPs (corrected P = 0.027-0.058 for FEV(1)% predicted, corrected P = 0.015-0.033 for FEV(1)/FVC). This study highlights the importance of early recognition of a decreased FEV(1) in healthy subjects without evident pulmonary diseases because it predicts a rapid decline in FEV(1) irrespective of smoking status. Our series of studies identified TSLP variants as a potential susceptibility locus to asthma and to lower lung function in non-COPD, nonasthmatic healthy subjects, which may support the contention that genetic determinants of lung function influence susceptibility to asthma.

Project description:BackgroundThe rate of forced expiratory volume in 1 second (FEV1) decline ("beta") is a marker of chronic obstructive pulmonary disease risk. The reduction in beta after quitting smoking is an upper limit for the reduction achievable from switching to novel nicotine delivery products. We review available evidence to estimate this reduction and quantify the relationship of smoking to beta.MethodsStudies were identified, in healthy individuals or patients with respiratory disease, that provided data on beta over at least 2 years of follow-up, separately for those who gave up smoking and other smoking groups. Publications to June 2010 were considered. Independent beta estimates were derived for four main smoking groups: never smokers, ex-smokers (before baseline), quitters (during follow-up) and continuing smokers. Unweighted and inverse variance-weighted regression analyses compared betas in the smoking groups, and in continuing smokers by amount smoked, and estimated whether beta or beta differences between smoking groups varied by age, sex and other factors.ResultsForty-seven studies had relevant data, 28 for both sexes and 19 for males. Sixteen studies started before 1970. Mean follow-up was 11 years. On the basis of weighted analysis of 303 betas for the four smoking groups, never smokers had a beta 10.8 mL/yr (95% confidence interval (CI), 8.9 to 12.8) less than continuing smokers. Betas for ex-smokers were 12.4 mL/yr (95% CI, 10.1 to 14.7) less than for continuing smokers, and for quitters, 8.5 mL/yr (95% CI, 5.6 to 11.4) less. These betas were similar to that for never smokers. In continuing smokers, beta increased 0.33 mL/yr per cigarette/day. Beta differences between continuing smokers and those who gave up were greater in patients with respiratory disease or with reduced baseline lung function, but were not clearly related to age or sex.ConclusionThe available data have numerous limitations, but clearly show that continuing smokers have a beta that is dose-related and over 10 mL/yr greater than in never smokers, ex-smokers or quitters. The greater decline in those with respiratory disease or reduced lung function is consistent with some smokers having a more rapid rate of FEV1 decline. These results help in designing studies comparing continuing smokers of conventional cigarettes and switchers to novel products.

Dataset Information

Cross-shift airway responses and long-term decline in FEV1 in cotton textile workers.

Rationale

Objectives

Methods

Measurements and main results

Conclusions

Publications

Cross-shift airway responses and long-term decline in FEV1 in cotton textile workers.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets