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A large scale gene-centric association study of lung function in newly-hired female cotton textile workers with endotoxin exposure.

ABSTRACT: Occupational exposure to endotoxin is associated with decrements in pulmonary function, but how much variation in this association is explained by genetic variants is not well understood.We aimed to identify single nucleotide polymorphisms (SNPs) that are associated with the rate of forced expiratory volume in one second (FEV1) decline by a large scale genetic association study in newly-hired healthy young female cotton textile workers.DNA samples were genotyped using the Illumina Human CVD BeadChip. Change rate in FEV1 was modeled as a function of each SNP genotype in linear regression model with covariate adjustment. We controlled the type 1 error in study-wide level by permutation method. The false discovery rate (FDR) and the family-wise error rate (FWER) were set to be 0.10 and 0.15 respectively.Two SNPs were found to be significant (P<6.29×10(-5)), including rs1910047 (P?=?3.07×10(-5), FDR?=?0.0778) and rs9469089 (P?=?6.19×10(-5), FDR?=?0.0967), as well as other eight suggestive (P<5×10(-4)) associated SNPs. Gene-gene and gene-environment interactions were also observed, such as rs1910047 and rs1049970 (P?=?0.0418, FDR?=?0.0895); rs9469089 and age (P?=?0.0161, FDR?=?0.0264). Genetic risk score analysis showed that the more risk loci the subjects carried, the larger the rate of FEV1 decline occurred (P trend?=?3.01×10(-18)). However, the association was different among age subgroups (P?=?7.11×10(-6)) and endotoxin subgroups (P?=?1.08×10(-2)). Functional network analysis illustrates potential biological connections of all interacted genes.Genetic variants together with environmental factors interact to affect the rate of FEV1 decline in cotton textile workers.

SUBMITTER: Zhang R

PROVIDER: S-EPMC3602449 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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A large scale gene-centric association study of lung function in newly-hired female cotton textile workers with endotoxin exposure.

Zhang Ruyang R Zhao Yang Y Chu Minjie M Mehta Amar A Wei Yongyue Y Liu Yao Y Xun Pengcheng P Bai Jianling J Yu Hao H Su Li L Zhang Hongxi H Hu Zhibin Z Shen Hongbing H Chen Feng F Christiani David C DC

PloS one 20130319 3

<h4>Background</h4>Occupational exposure to endotoxin is associated with decrements in pulmonary function, but how much variation in this association is explained by genetic variants is not well understood.<h4>Objective</h4>We aimed to identify single nucleotide polymorphisms (SNPs) that are associated with the rate of forced expiratory volume in one second (FEV1) decline by a large scale genetic association study in newly-hired healthy young female cotton textile workers.<h4>Methods</h4>DNA sam ...[more]

PMID: 23527081

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Project description:Background and aimOne of the main tasks of the healthcare human resource management is to maintain and retain professional staff. The high level turnover of professional staff may reduce the quality of healthcare service delivery. Therefore, this study investigated the factors associated with the turnover of the newly recruited healthcare professionals using survival analysis method in Iran.Materials and methodsThis historical cohort analysis comprised 6811 employees who began working at Mashhad University of Medical Sciences between 2005 and 2020. Employees recruited at any of the university's units between the years 2005 to 2019 were included. We used appropriate descriptive indices and Log-rank test and the Cox proportional-hazards model to assess the staff turnover. A significance level of 0.05 was used for all tests.ResultsThe findings of the survival analysis showed that the probability of turnover in one year, two years, and five years of employment were 0.12, 0.16, and 0.27. Based on the findings of the Log-rank test, the probability of turnover in entire of the study period was not statistically different between male and female (p = 0.573), and likewise between employees with healthcare occupations and non-healthcare occupations (p = 0.351). Employees whose current workplace and birthplace were not similar had a significantly higher probability of turnover (p < 0.001). Accordingly, the Cox regression result showed, the risk of turnover for the singles was 1.22 times higher than the married. For the Ph.D degree was 3.23 times higher compared to those with a diploma or an associate degree, and for a bachelor's or master's degree was 2.06 times more likely to change their workplace than those with a diploma or an associate degree.ConclusionPolicies promoting the recruitment of native-born professionals, given priority to the married candidates than single ones, and/or recurring candidates to pledge to stay in the locality of recruitment site can increase the staff retention and reduce the costs of staff turnover including re-hiring, initial and on-the-job training, accommodation, and other extra living consumptions away from home and family.

Dataset Information

A large scale gene-centric association study of lung function in newly-hired female cotton textile workers with endotoxin exposure.

Publications

A large scale gene-centric association study of lung function in newly-hired female cotton textile workers with endotoxin exposure.

Similar Datasets

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