Ontology highlight
ABSTRACT:
SUBMITTER: Heng S
PROVIDER: S-EPMC2720136 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Heng Sabrina S Gryncel Kimberly R KR Kantrowitz Evan R ER
Bioorganic & medicinal chemistry 20090419 11
The identification of a proper lead compound for fructose 1,6-bisphosphatase (FBPase) is a critical step in the process of developing novel therapeutics against type-2 diabetes. Herein, we have successfully generated a library of allosteric inhibitors against FBPase as potential anti-diabetic drugs, of which, the lead compound 1b was identified through utilizing a virtual high-throughput screening (vHTS) system, which we have developed. The thiazole-based core structure was synthesized via the c ...[more]