Ontology highlight
ABSTRACT:
SUBMITTER: Heng S
PROVIDER: S-EPMC3004218 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
European journal of medicinal chemistry 20100113 4
Natural products often contain unusual scaffold structures that may be elaborated by combinatorial methods to develop new drug-like molecules. Visual inspection of more than 128 natural products with some type of anti-diabetic activity suggested that a subset might provide novel scaffolds for designing potent inhibitors against fructose 1,6-bisphosphatase (FBPase), an enzyme critical in the control of gluconeogenesis. Using in silico docking methodology, these were evaluated to determine those t ...[more]