Ontology highlight
ABSTRACT:
SUBMITTER: Smieja J
PROVIDER: S-EPMC2720726 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Smieja Jaroslaw J Jamaluddin Mohammad M Brasier Allan R AR Kimmel Marek M
Bioinformatics (Oxford, England) 20080819 20
<h4>Motivation</h4>Interferon-beta induced JAK-STAT signaling pathways contribute to mucosal immune recognition and an anti-viral state. Though the main molecular mechanisms constituting these pathways are known, neither the detailed structure of the regulatory network, nor its dynamics has yet been investigated. The objective of this work is to build a mathematical model for the pathway that would serve two purposes: (1) to reproduce experimental results in simulation of both early and late res ...[more]