Antiviral interferon-beta signaling induced by designed transcription activator-like effectors (TALE).
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ABSTRACT:
SUBMITTER: Renner I
PROVIDER: S-EPMC4255017 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Antiviral interferon-beta signaling induced by designed transcription activator-like effectors (TALE).
Renner Ivonne I Funk Nancy N Geissler Rene R Friedrich Susann S Penzel Anika A Behrens Sven-Erik SE
PloS one 20141203 12
Here we show that designed transcription activator-like effectors (TALEs) that bind to defined areas of the interferon beta promoter are capable to induce IFN-beta expression and signaling in human cells. Importantly, TALE-mediated IFN-beta signaling occurs independently of pathogen pattern recognition but effectively prohibits viral RNA replication as demonstrated with a hepatitis C virus replicon. TALEs were thus indicated to be valuable tools in various applications addressing, for example, v ...[more]
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