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Total lymphocyte count: not a surrogate marker for risk of death in HIV-infected Ugandan children.

ABSTRACT: OBJECTIVES:To determine the utility of total lymphocyte count (TLC) in predicting the 12-month mortality in HIV-infected Ugandan children and to correlate TLC and CD4 cell %. DESIGN:This is a retrospective data analysis of clinical and laboratory data collected prospectively on 128 HIV-infected children in the HIV Network for Prevention Trials 012 trial. METHODS:TLC and CD4 cell % measurements were obtained at birth, 14 weeks, and 12, 24, 36, 48, and 60 months of age and assessed with respect to risk of death within 12 months. RESULTS:Median TLC per microliter (CD4 cell %) was 4150 (41%) at birth, 4900 (24%) at 12 months, 4300 (19%) at 24 months, 4150 (19%) at 36 months, 4100 (18%) at 48 months, and 3800 (20%) at 60 months. The highest risk of mortality within 12 months was 34% - 37% at birth and declined to 13%-15% at 24 months regardless of TLC measurement. The correlation between CD4 cell % and TLC was extremely low overall (r = 0.01). CONCLUSIONS:The TLC did not predict a risk of progression to death within 12 months in HIV-infected Ugandan children. Therefore, TLC alone may not be a useful surrogate marker for determining those children at highest risk of death, who require antiretroviral therapy most urgently.

SUBMITTER: Musoke PM

PROVIDER: S-EPMC2721476 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature

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Total lymphocyte count: not a surrogate marker for risk of death in HIV-infected Ugandan children.

Musoke Philippa M PM Young Alicia M AM Owor Maxensia A MA Lubega Irene R IR Brown Elizabeth R ER Mmiro Francis A FA Mofenson Lynne M LM Jackson J Brooks JB Fowler Mary Glenn MG Guay Laura A LA

Journal of acquired immune deficiency syndromes (1999) 20081001 2

<h4>Objectives</h4>To determine the utility of total lymphocyte count (TLC) in predicting the 12-month mortality in HIV-infected Ugandan children and to correlate TLC and CD4 cell %.<h4>Design</h4>This is a retrospective data analysis of clinical and laboratory data collected prospectively on 128 HIV-infected children in the HIV Network for Prevention Trials 012 trial.<h4>Methods</h4>TLC and CD4 cell % measurements were obtained at birth, 14 weeks, and 12, 24, 36, 48, and 60 months of age and as ...[more]

PMID: 18769352

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Dataset Information

Total lymphocyte count: not a surrogate marker for risk of death in HIV-infected Ugandan children.

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Total lymphocyte count: not a surrogate marker for risk of death in HIV-infected Ugandan children.

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