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Neurocognitive and motor deficits in HIV-infected Ugandan children with high CD4 cell counts.

ABSTRACT: Human immunodeficiency virus (HIV) infection causes neurocognitive or motor function deficits in children with advanced disease, but it is unclear whether children with CD4 cell measures above the World Health Organization (WHO) thresholds for antiretroviral therapy (ART) initiation suffer significant impairment.The neurocognitive and motor functions of HIV-infected ART-naive Ugandan children aged 6-12 years with CD4 cell counts of >350?cells/?L and CD4 cell percentage of >15% were compared with those of HIV-uninfected children, using the Test of Variables of Attention (TOVA), the Kaufman Assessment Battery for Children, second edition (KABC-2), and the Bruininks-Oseretsky Test of Motor Proficiency, second edition (BOT-2).Ninety-three HIV-infected children (median CD4 cell count, 655?cells/?L; plasma HIV RNA level, 4.7?log(10) copies/mL) were compared to 106 HIV-uninfected children. HIV-infected children performed worse on TOVA visual reaction times (multivariate analysis of covariance; P?=?.006); KABC-2 sequential processing (P?=?.005), simultaneous processing (P?=?.039), planning/reasoning (P?=?.023), and global performance (P?=?.024); and BOT-2 total motor proficiency (P?=?.003). High plasma HIV RNA level was associated with worse performance in 10 cognitive measures and 3 motor measures. In analysis of only WHO clinical stage 1 or 2 HIV-infected children (n?=?68), significant differences between the HIV-infected and HIV-uninfected groups (P?15%. Study of whether early initiation of ART could prevent or reverse such deficits is needed.

SUBMITTER: Ruel TD

PROVIDER: S-EPMC3297647 | biostudies-other | 2012 Apr

REPOSITORIES: biostudies-other

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Neurocognitive and motor deficits in HIV-infected Ugandan children with high CD4 cell counts.

Ruel Theodore D TD Boivin Michael J MJ Boal Hannah E HE Bangirana Paul P Charlebois Edwin E Havlir Diane V DV Rosenthal Philip J PJ Dorsey Grant G Achan Jane J Akello Carolyne C Kamya Moses R MR Wong Joseph K JK

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20120204 7

<h4>Background</h4>Human immunodeficiency virus (HIV) infection causes neurocognitive or motor function deficits in children with advanced disease, but it is unclear whether children with CD4 cell measures above the World Health Organization (WHO) thresholds for antiretroviral therapy (ART) initiation suffer significant impairment.<h4>Methods</h4>The neurocognitive and motor functions of HIV-infected ART-naive Ugandan children aged 6-12 years with CD4 cell counts of >350 cells/μL and CD4 cell pe ...[more]

PMID: 22308272

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Dataset Information

Neurocognitive and motor deficits in HIV-infected Ugandan children with high CD4 cell counts.

Publications

Neurocognitive and motor deficits in HIV-infected Ugandan children with high CD4 cell counts.

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