Ontology highlight
ABSTRACT:
SUBMITTER: Rush JS
PROVIDER: S-EPMC2721638 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Rush Jason S JS Bertozzi Carolyn R CR
Journal of the American Chemical Society 20080823 37
Formylglycine generating enzyme (FGE) performs a critical posttranslational modification of type I sulfatases, converting cysteine within the motif CxPxR to the aldehyde-bearing residue formylglycine (FGly). This concise motif can be installed within heterologous proteins as a genetically encoded "aldehyde tag" for site-specific labeling with aminooxy- or hydrazide-functionalized probes. In this report, we screened FGEs from M. tuberculosis and S. coelicolor against synthetic peptide libraries a ...[more]