Ontology highlight
ABSTRACT:
SUBMITTER: Oishi K
PROVIDER: S-EPMC2722283 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Oishi Koji K Watatani Kenji K Itoh Yasuhiro Y Okano Hideyuki H Guillemot François F Nakajima Kazunori K Gotoh Yukiko Y
Proceedings of the National Academy of Sciences of the United States of America 20090619 31
Extracellular stimuli regulate neuronal differentiation and subtype specification during brain development, although the intracellular signaling pathways that mediate these processes remain largely unclear. We now show that the PDK1-Akt pathway regulates differentiation of telencephalic neural precursor cells (NPCs). Active Akt promotes differentiation of NPC into gamma-aminobutyric acid-containing (GABAergic) but not glutamatergic neurons. Disruption of the Pdk1 gene or expression of dominant-n ...[more]