Ontology highlight
ABSTRACT:
SUBMITTER: Nakano M
PROVIDER: S-EPMC2722348 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Nakano Masakazu M Ikeda Yoko Y Taniguchi Takazumi T Yagi Tomohito T Fuwa Masahiro M Omi Natsue N Tokuda Yuichi Y Tanaka Masami M Yoshii Kengo K Kageyama Masaaki M Naruse Shigeta S Matsuda Akira A Mori Kazuhiko K Kinoshita Shigeru S Tashiro Kei K
Proceedings of the National Academy of Sciences of the United States of America 20090722 31
Primary open-angle glaucoma (POAG) is the major type of glaucoma. To discover genetic markers associated with POAG, we examined a total of 1,575 Japanese subjects in a genome-wide association study (stage 1) and a subsequent study (stage 2). Both studies were carried out at a single institution. In the stage 1 association study, we compared SNPs between 418 POAG patients and 300 control subjects. First, low-quality data were eliminated by a stringent filter, and 331,838 autosomal SNPs were selec ...[more]