Ontology highlight
ABSTRACT:
SUBMITTER: Scheetz TE
PROVIDER: S-EPMC3594156 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Scheetz Todd E TE Fingert John H JH Wang Kai K Kuehn Markus H MH Knudtson Kevin L KL Alward Wallace L M WL Boldt H Culver HC Russell Stephen R SR Folk James C JC Casavant Thomas L TL Braun Terry A TA Clark Abbot F AF Stone Edwin M EM Sheffield Val C VC
PloS one 20130311 3
Glaucoma and age-related macular degeneration (AMD) are the two leading causes of visual loss in the United States. We utilized a novel study design to perform a genome-wide association for both primary open angle glaucoma (POAG) and AMD. This study design utilized a two-stage process for hypothesis generation and validation, in which each disease cohort was utilized as a control for the other. A total of 400 POAG patients and 400 AMD patients were ascertained and genotyped at 500,000 loci. This ...[more]