Ontology highlight
ABSTRACT:
SUBMITTER: Junn E
PROVIDER: S-EPMC2722353 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Junn Eunsung E Lee Kang-Woo KW Jeong Byeong Seon BS Chan Teresa W TW Im Joo-Young JY Mouradian M Maral MM
Proceedings of the National Academy of Sciences of the United States of America 20090723 31
alpha-Synuclein is a key protein in Parkinson's disease (PD) because it accumulates as fibrillar aggregates in pathologic hallmark features in affected brain regions, most notably in nigral dopaminergic neurons. Intraneuronal levels of this protein appear critical in mediating its toxicity, because multiplication of its gene locus leads to autosomal dominant PD, and transgenic animal models overexpressing human alpha-synuclein manifest impaired function or decreased survival of dopaminergic neur ...[more]