Ontology highlight
ABSTRACT:
SUBMITTER: Robertson RB
PROVIDER: S-EPMC2722365 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Robertson Ragan B RB Moses Dana N DN Kwon YoungHo Y Chan Pamela P Chi Peter P Klein Hannah H Sung Patrick P Greene Eric C EC
Proceedings of the National Academy of Sciences of the United States of America 20090721 31
Rad51 is a core component of the eukaryotic homologous recombination machinery and is responsible for key mechanistic steps during strand invasion. Higher order oligomers of Rad51 display a remarkable degree of structural variation, forming rings, compressed filaments, and elongated filaments. It is unclear whether Rad51 can transition directly between these different oligomeric structures without disassembling first into monomers. We have used single-molecule microscopy to investigate the behav ...[more]