Ontology highlight
ABSTRACT:
SUBMITTER: Lynch EM
PROVIDER: S-EPMC6954954 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Lynch Eric M EM Kollman Justin M JM
Nature structural & molecular biology 20191223 1
Many enzymes assemble into defined oligomers, providing a mechanism for cooperatively regulating activity. Recent studies have described a mode of regulation in which enzyme activity is modulated by polymerization into large-scale filaments. Here we describe an ultrasensitive form of polymerization-based regulation employed by human CTP synthase 2 (CTPS2). Cryo-EM structures reveal that CTPS2 filaments dynamically switch between active and inactive forms in response to changes in substrate and p ...[more]