Ontology highlight
ABSTRACT:
SUBMITTER: North TE
PROVIDER: S-EPMC2722870 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
North Trista E TE Goessling Wolfram W Peeters Marian M Li Pulin P Ceol Craig C Lord Allegra M AM Weber Gerhard J GJ Harris James J Cutting Claire C CC Huang Paul P Dzierzak Elaine E Zon Leonard I LI
Cell 20090501 4
During vertebrate embryogenesis, hematopoietic stem cells (HSCs) arise in the aorta-gonads-mesonephros (AGM) region. We report here that blood flow is a conserved regulator of HSC formation. In zebrafish, chemical blood flow modulators regulated HSC development, and silent heart (sih) embryos, lacking a heartbeat and blood circulation, exhibited severely reduced HSCs. Flow-modifying compounds primarily affected HSC induction after the onset of heartbeat; however, nitric oxide (NO) donors regulat ...[more]