Ontology highlight
ABSTRACT:
SUBMITTER: Cutler C
PROVIDER: S-EPMC3811179 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Cutler Corey C Multani Pratik P Robbins David D Kim Haesook T HT Le Thuy T Hoggatt Jonathan J Pelus Louis M LM Desponts Caroline C Chen Yi-Bin YB Rezner Betsy B Armand Philippe P Koreth John J Glotzbecker Brett B Ho Vincent T VT Alyea Edwin E Isom Marlisa M Kao Grace G Armant Myriam M Silberstein Leslie L Hu Peirong P Soiffer Robert J RJ Scadden David T DT Ritz Jerome J Goessling Wolfram W North Trista E TE Mendlein John J Ballen Karen K Zon Leonard I LI Antin Joseph H JH Shoemaker Daniel D DD
Blood 20130830 17
Umbilical cord blood (UCB) is a valuable source of hematopoietic stem cells (HSCs) for use in allogeneic transplantation. Key advantages of UCB are rapid availability and less stringent requirements for HLA matching. However, UCB contains an inherently limited HSC count, which is associated with delayed time to engraftment, high graft failure rates, and early mortality. 16,16-Dimethyl prostaglandin E2 (dmPGE2) was previously identified to be a critical regulator of HSC homeostasis, and we hypoth ...[more]