Ontology highlight
ABSTRACT:
SUBMITTER: Chen Y
PROVIDER: S-EPMC2722925 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Chen Yunting Y Jakoncic Jean J Wang Jin J Zheng Xiliang X Carpino Nick N Nassar Nicolas N
Biochemistry 20081021 46
Here, we present the crystal structure of the ecdysone phosphate phosphatase (EPPase) phosphoglycerate mutase (PGM) homology domain, the first structure of a steroid phosphate phosphatase. The structure reveals an alpha/beta-fold common to members of the two histidine (2H)-phosphatase superfamily with strong homology to the Suppressor of T-cell receptor signaling-1 (Sts-1 PGM) protein. The putative EPPase PGM active site contains signature residues shared by 2H-phosphatase enzymes, including a c ...[more]