Detection and Identification of Bioanalytes with High Resolution LSPR Spectroscopy and MALDI Mass Spectrometry.
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ABSTRACT:
SUBMITTER: Anker JN
PROVIDER: S-EPMC2723955 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Publications
Detection and Identification of Bioanalytes with High Resolution LSPR Spectroscopy and MALDI Mass Spectrometry.
Anker Jeffrey N JN Hall W Paige WP Lambert Mary P MP Velasco Pauline T PT Mrksich Milan M Klein William L WL Van Duyne Richard P RP
The journal of physical chemistry. C, Nanomaterials and interfaces 20090301 15
High resolution localized surface plasmon resonance (HR-LSPR) sensors were combined with matrix assisted laser desorption ionization mass spectrometry (MALDI-MS) for the first time. LSPR sensors provide real-time label-free detection of molecular adsorption. Subsequent MALDI-MS analysis enables identification of the adsorbed molecules. This synergistic LSPR-MS approach was applied to the detection and identification of amyloid beta oligomers which play an important role in the molecular pathogen ...[more]
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