Ontology highlight
ABSTRACT:
SUBMITTER: Fuller BG
PROVIDER: S-EPMC2724008 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Fuller Brian G BG Lampson Michael A MA Foley Emily A EA Rosasco-Nitcher Sara S Le Kim V KV Tobelmann Page P Brautigan David L DL Stukenberg P Todd PT Kapoor Tarun M TM
Nature 20080507 7198
Proper partitioning of the contents of a cell between two daughters requires integration of spatial and temporal cues. The anaphase array of microtubules that self-organize at the spindle midzone contributes to positioning the cell-division plane midway between the segregating chromosomes. How this signalling occurs over length scales of micrometres, from the midzone to the cell cortex, is not known. Here we examine the anaphase dynamics of protein phosphorylation by aurora B kinase, a key mitot ...[more]