Ontology highlight
ABSTRACT:
SUBMITTER: Hannabuss J
PROVIDER: S-EPMC6616649 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Hannabuss Jonathon J Lera-Ramirez Manuel M Cade Nicholas I NI Fourniol Franck J FJ Nédélec François F Surrey Thomas T
Current biology : CB 20190620 13
In anaphase spindles, antiparallel microtubules associate to form tight midzone bundles, as required for functional spindle architecture and correct chromosome segregation. Several proteins selectively bind to these overlaps to control cytokinesis. How midzone bundles assemble is poorly understood. Here, using an in vitro reconstitution approach, we demonstrate that minimal midzone bundles can reliably self-organize in solution from dynamic microtubules, the microtubule crosslinker PRC1, and the ...[more]