Ontology highlight
ABSTRACT:
SUBMITTER: Greenberg MJ
PROVIDER: S-EPMC2724231 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Greenberg Michael J MJ Mealy Tanya R TR Watt James D JD Jones Michelle M Szczesna-Cordary Danuta D Moore Jeffrey R JR
American journal of physiology. Regulatory, integrative and comparative physiology 20090520 2
Phosphorylation of the myosin regulatory light chain (RLC) in skeletal muscle has been proposed to act as a molecular memory of recent activation by increasing the rate of force development, ATPase activity, and isometric force at submaximal activation in fibers. It has been proposed that these effects stem from phosphorylation-induced movement of myosin heads away from the thick filament backbone. In this study, we examined the molecular effects of skeletal muscle myosin RLC phosphorylation usi ...[more]