Ontology highlight
ABSTRACT:
SUBMITTER: Tatro ET
PROVIDER: S-EPMC2724600 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Tatro Erick T ET Everall Ian P IP Kaul Marcus M Achim Cristian L CL
Brain research 20090621
Mood disorders associated with dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis are common psychiatric conditions. The glucocorticoid receptor (GR) is a steroid-activated nuclear receptor that, upon binding to cortisol, translocates to the nucleus where it targets genes related to neuronal metabolism and plasticity. In patients suffering from major depressive disorder (MDD), hypercortisolemia is a common finding. In the current study we investigated the molecular events associated wi ...[more]