Ontology highlight
ABSTRACT:
SUBMITTER: Baida G
PROVIDER: S-EPMC6205168 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Baida Gleb G Bhalla Pankaj P Yemelyanov Alexander A Stechschulte Lance A LA Shou Weinian W Readhead Ben B Dudley Joel T JT Sánchez Edwin R ER Budunova Irina I
Oncotarget 20181005 78
FKBP51 (FK506-binding protein 51) is a known co-chaperone and regulator of the glucocorticoid receptor (GR), which usually attenuates its activity. FKBP51 is one of the major GR target genes in skin, but its role in clinical effects of glucocorticoids is not known. Here, we used FKBP51 knockout (KO) mice to determine FKBP51's role in the major adverse effect of topical glucocorticoids, skin atrophy. Unexpectedly, we found that all skin compartments (epidermis, dermis, dermal adipose and CD34+ st ...[more]