Ontology highlight
ABSTRACT:
SUBMITTER: Watts JM
PROVIDER: S-EPMC2724670 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Watts Joseph M JM Dang Kristen K KK Gorelick Robert J RJ Leonard Christopher W CW Bess Julian W JW Swanstrom Ronald R Burch Christina L CL Weeks Kevin M KM
Nature 20090801 7256
Single-stranded RNA viruses encompass broad classes of infectious agents and cause the common cold, cancer, AIDS and other serious health threats. Viral replication is regulated at many levels, including the use of conserved genomic RNA structures. Most potential regulatory elements in viral RNA genomes are uncharacterized. Here we report the structure of an entire HIV-1 genome at single nucleotide resolution using SHAPE, a high-throughput RNA analysis technology. The genome encodes protein stru ...[more]