Ontology highlight
ABSTRACT:
SUBMITTER: Peterson YK
PROVIDER: S-EPMC2726652 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Peterson Yuri K YK Wang Xiang S XS Casey Patrick J PJ Tropsha Alexander A
Journal of medicinal chemistry 20090701 14
Geranylgeranylation is critical to the function of several proteins including Rho, Rap1, Rac, Cdc42, and G-protein gamma subunits. Geranylgeranyltransferase type I (GGTase-I) inhibitors (GGTIs) have therapeutic potential to treat inflammation, multiple sclerosis, atherosclerosis, and many other diseases. Following our standard workflow, we have developed and rigorously validated quantitative structure-activity relationship (QSAR) models for 48 GGTIs using variable selection k nearest neighbor (k ...[more]