Ontology highlight
ABSTRACT:
SUBMITTER: Jindrichova M
PROVIDER: S-EPMC2727158 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Jindrichova Marie M Vavra Vojtech V Obsil Tomas T Stojilkovic Stanko S SS Zemkova Hana H
Journal of neurochemistry 20090501 3
The functional relevance of aromatic residues in the upper part of the transmembrane domain-1 of purinergic P2X receptors (P2XRs) was examined. Replacement of the conserved Tyr residue with Ala had a receptor-specific effect: the P2X1R was non-functional, the P2X2R, P2X4R, and P2X3R exhibited enhanced sensitivity to ATP and alphabeta-meATP accompanied by prolonged decay of current after washout of agonists, and the P2X7R sensitivity for agonists was not affected, though decay of current was dela ...[more]