Ontology highlight
ABSTRACT:
SUBMITTER: Low SE
PROVIDER: S-EPMC2583207 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Low Sean E SE Kuwada John Y JY Hume Richard I RI
Purinergic signalling 20081011 4
Several zebrafish P2X receptors (zP2X(1), zP2X(2), and zP2X(5.1)) have been reported to produce little or no current although their mammalian orthologs produce functional homomeric receptors. We isolated new cDNA clones for these P2X receptors that revealed sequence variations in each. The new variants of zP2X(1) and zP2X(5.1) produced substantial currents when expressed by Xenopus oocytes, however the new variant of zP2X(2) was still nonfunctional. zP2X(2) lacks two lysine residues essential fo ...[more]