Ontology highlight
ABSTRACT:
SUBMITTER: Karpac J
PROVIDER: S-EPMC2727449 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Aging cell 20090409 3
Adaptation to environmental challenges is critical for the survival of an organism. Repression of Insulin/IGF Signaling (IIS) by stress-responsive Jun-N-terminal Kinase (JNK) signaling is emerging as a conserved mechanism that allows reallocating resources from anabolic to repair processes under stress conditions. JNK activation in Insulin-producing cells (IPCs) is sufficient to repress Insulin and Insulin-like peptide (ILP) expression in rats and flies, but the significance of this interaction ...[more]