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Insulin signaling is acutely required for long-term memory in Drosophila.

ABSTRACT: Memory formation has been shown recently to be dependent on energy status in Drosophila. A well-established energy sensor is the insulin signaling (InS) pathway. Previous studies in various animal models including human have revealed the role of insulin levels in short-term memory but its role in long-term memory remains less clear. We therefore investigated genetically the spatial and temporal role of InS using the olfactory learning and long-term memory model in Drosophila. We found that InS is involved in both learning and memory. InS in the mushroom body is required for learning and long-term memory whereas long-term memory specifically is impaired after InS signaling disruption in the ellipsoid body, where it regulates the level of p70s6k, a downstream target of InS and a marker of protein synthesis. Finally, we show also that InS is acutely required for long-term memory formation in adult flies.

SUBMITTER: Chambers DB

PROVIDER: S-EPMC4354381 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Insulin signaling is acutely required for long-term memory in Drosophila.

Chambers Daniel B DB Androschuk Alaura A Rosenfelt Cory C Langer Steven S Harding Mark M Bolduc Francois V FV

Frontiers in neural circuits 20150310

Memory formation has been shown recently to be dependent on energy status in Drosophila. A well-established energy sensor is the insulin signaling (InS) pathway. Previous studies in various animal models including human have revealed the role of insulin levels in short-term memory but its role in long-term memory remains less clear. We therefore investigated genetically the spatial and temporal role of InS using the olfactory learning and long-term memory model in Drosophila. We found that InS i ...[more]

PMID: 25805973

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