Ontology highlight
ABSTRACT:
SUBMITTER: Miyashita N
PROVIDER: S-EPMC2727648 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Miyashita Naoyuki N Straub John E JE Thirumalai D D Sugita Yuji Y
Journal of the American Chemical Society 20090301 10
Abeta peptide is an essential protein in the pathogenesis of Alzheimer's disease and is derived from amyloid precursor protein (APP) in the membrane by beta- and gamma-secretase cleavage. An experimental study has shown that a pairwise replacement of Gly with Leu in APP enhances homodimerization but leads to a drastic reduction of Abeta secretion. To resolve this apparent discrepancy, we predicted the wild-type (WT) and mutant APP dimer conformations by replica-exchange molecular dynamics simula ...[more]