Ontology highlight
ABSTRACT:
SUBMITTER: Nagai T
PROVIDER: S-EPMC6369401 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Nagai Tetsuro T Tama Florence F Miyashita Osamu O
Biophysical journal 20181213 3
Cryo-cooling is routinely performed before x-ray diffraction image collection to reduce the damage to crystals due to ionizing radiation. It has been suggested that although backbone structures are usually very similar between room temperature and cryo-temperature, cryo-cooling may hamper biologically relevant dynamics. In this study, the crystal of Escherichia coli dihydrofolate reductase is studied with replica-exchange molecular dynamics simulation, and the results are compared with the cryst ...[more]