Ontology highlight
ABSTRACT:
SUBMITTER: Cao H
PROVIDER: S-EPMC2728618 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Cao Haiming H Gerhold Kristin K Mayers Jared R JR Wiest Michelle M MM Watkins Steven M SM Hotamisligil Gökhan S GS
Cell 20080901 6
Dysregulation of lipid metabolism in individual tissues leads to systemic disruption of insulin action and glucose metabolism. Utilizing quantitative lipidomic analyses and mice deficient in adipose tissue lipid chaperones aP2 and mal1, we explored how metabolic alterations in adipose tissue are linked to whole-body metabolism through lipid signals. A robust increase in de novo lipogenesis rendered the adipose tissue of these mice resistant to the deleterious effects of dietary lipid exposure. S ...[more]