Ontology highlight
ABSTRACT:
SUBMITTER: Herman MA
PROVIDER: S-EPMC3341994 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Herman Mark A MA Peroni Odile D OD Villoria Jorge J Schön Michael R MR Abumrad Nada A NA Blüher Matthias M Klein Samuel S Kahn Barbara B BB
Nature 20120401 7394
The prevalence of obesity and type 2 diabetes is increasing worldwide and threatens to shorten lifespan. Impaired insulin action in peripheral tissues is a major pathogenic factor. Insulin stimulates glucose uptake in adipose tissue through the GLUT4 (also known as SLC2A4) glucose transporter, and alterations in adipose tissue GLUT4 expression or function regulate systemic insulin sensitivity. Downregulation of human and mouse adipose tissue GLUT4 occurs early in diabetes development. Here we re ...[more]