Ontology highlight
ABSTRACT:
SUBMITTER: Tagore DM
PROVIDER: S-EPMC2730040 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Tagore Debarati M DM Nolte Whitney M WM Neveu John M JM Rangel Roberto R Guzman-Rojas Liliana L Pasqualini Renata R Arap Wadih W Lane William S WS Saghatelian Alan A
Nature chemical biology 20081116 1
Peptide metabolism is a complex process that involves many proteins working in concert. Mass spectrometry-based global peptide profiling of mice lacking dipeptidyl peptidase 4 (DPP4) identified endogenous DPP4 substrates and revealed an unrecognized pathway during proline peptide catabolism that interlinks aminopeptidase and DPP4 activities. Together, these studies elucidate specific aspects of DPP4-regulated metabolism and, more generally, highlight the utility of global peptide profiling for s ...[more]