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Accumulation of acyl-enzyme in DD-peptidase-catalysed reactions with analogues of peptide substrates.


ABSTRACT: Thioester substrates can be used to study the hydrolysis and transfer reactions catalysed by beta-lactamases and DD-peptidases. With the latter enzymes, accumulation of the acyl-enzyme can be detected directly. The efficiency of various amines as acceptor substrates was in excellent agreement with previous results obtained with peptide substrates of the DD-peptidases. The results indicated the presence of a specific binding site for the acceptor substrates. Although most of the results agreed well with a simple partition model, more elaborate hypotheses will be needed to account for all the data presented.

SUBMITTER: Jamin M 

PROVIDER: S-EPMC1130576 | biostudies-other | 1991 Dec

REPOSITORIES: biostudies-other

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