Unknown

Dataset Information

0

Accumulation of acyl-enzyme in DD-peptidase-catalysed reactions with analogues of peptide substrates.


ABSTRACT: Thioester substrates can be used to study the hydrolysis and transfer reactions catalysed by beta-lactamases and DD-peptidases. With the latter enzymes, accumulation of the acyl-enzyme can be detected directly. The efficiency of various amines as acceptor substrates was in excellent agreement with previous results obtained with peptide substrates of the DD-peptidases. The results indicated the presence of a specific binding site for the acceptor substrates. Although most of the results agreed well with a simple partition model, more elaborate hypotheses will be needed to account for all the data presented.

SUBMITTER: Jamin M 

PROVIDER: S-EPMC1130576 | biostudies-other | 1991 Dec

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC1147644 | biostudies-other
| S-EPMC1146665 | biostudies-other
| S-EPMC1146664 | biostudies-other
| S-EPMC2730040 | biostudies-literature
| S-EPMC1184927 | biostudies-other
| S-EPMC5862990 | biostudies-literature
| S-EPMC5679075 | biostudies-literature
| S-EPMC1184644 | biostudies-other
| S-EPMC1647315 | biostudies-literature
| S-EPMC5488198 | biostudies-literature