Ontology highlight
ABSTRACT:
SUBMITTER: Annunziata CM
PROVIDER: S-EPMC2730509 | biostudies-literature | 2007 Aug
REPOSITORIES: biostudies-literature
Cancer cell 20070801 2
Mechanisms of constitutive NF-kappaB signaling in multiple myeloma are unknown. An inhibitor of IkappaB kinase beta (IKKbeta) targeting the classical NF-kappaB pathway was lethal to many myeloma cell lines. Several cell lines had elevated expression of NIK due to genomic alterations or protein stabilization, while others had inactivating mutations of TRAF3; both kinds of abnormality triggered the classical and alternative NF-kappaB pathways. A majority of primary myeloma patient samples and cell ...[more]