Ontology highlight
ABSTRACT:
SUBMITTER: Cavet ME
PROVIDER: S-EPMC2731942 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Cavet Megan E ME Smolock Elaine M EM Ozturk Oktay H OH World Cameron C Pang Jinjiang J Konishi Atsushi A Berk Bradford C BC
Arteriosclerosis, thrombosis, and vascular biology 20080221 5
<h4>Objective</h4>The receptor tyrosine kinase Axl and its ligand Gas6 are involved in the development of renal diabetic disease. In vascular smooth muscle cells (VSMCs) Axl is activated by reactive oxygen species and stimulates migration and cell survival, suggesting a role for Axl in the vascular complications of diabetes.<h4>Methods and results</h4>We investigated the effect of varying glucose concentration on Axl signaling in VSMCs. Glucose exerted powerful effects on Gas6-Axl signaling with ...[more]