Ontology highlight
ABSTRACT:
SUBMITTER: Chen YQ
PROVIDER: S-EPMC7485733 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Chen Yan-Qing YQ Zhou Hui-Min HM Chen Fang-Fang FF Liu Ya-Peng YP Han Lu L Song Ming M Wang Zhi-Hao ZH Zhang Wei W Shang Yuan-Yuan YY Zhong Ming M
Aging 20200727 16
Low serum testosterone level is associated with aging-related vascular stiffness, but the underlying mechanism is unclear. The Growth arrest-specific protein 6 (Gas6) /Axl pathway has been proved to play important roles in cell senescence. In this study, we intend to explore whether Gas6/Axl is involved in the effect of testosterone on vascular aging amelioration. Vascular aging models of wild type and Axl<sup>-/-</sup> mice were established by natural aging. Mice of these two gene types were ra ...[more]