Abyssinones and related flavonoids as potential steroidogenesis modulators.
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ABSTRACT:
SUBMITTER: Hatti KS
PROVIDER: S-EPMC2732035 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Publications
Abyssinones and related flavonoids as potential steroidogenesis modulators.
Hatti Kaushik S KS Diwakar Latha L Rao G Venkateswara GV Kush Anil A Reddy G Chandrasekara GC
Bioinformation 20090628 9
Abyssinones and related flavonoids were screened against 3 enzymes (3betaHSD, 17betaHSD and Aromatase) of steroidogenesis pathway. The virtual screening experiment shows high affinity for flavonones than their respective chalcones. A 4' -OH blocked prenylated flavonone 2b (2-(2', 2'-dimethyl chroman-6'-yl)-7-hydroxy chroman-4-one) had consistent binding affinity to all the three enzymes used in this study showing higher binding affinity to aromatase. A good correlation was observed between cytot ...[more]
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