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Super-coil me: sizing up centromeric nucleosomes.


ABSTRACT: Every chromosome needs a centromere for proper segregation during cell division. Centromeric chromatin wraps around histones, providing an anchor for kinetochore proteins and spindle attachment. It is clear why cells need centromeres, but how they form and what they look like is less so. Recent reports extend our understanding of chaperones involved in centromere formation. And other accounts of half-sized, right-handed nucleosomes have created an unexpected twist.

SUBMITTER: Hill E 

PROVIDER: S-EPMC2733755 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature

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Super-coil me: sizing up centromeric nucleosomes.

Hill Emma E   Williams Ruth R  

The Journal of cell biology 20090801 4


Every chromosome needs a centromere for proper segregation during cell division. Centromeric chromatin wraps around histones, providing an anchor for kinetochore proteins and spindle attachment. It is clear why cells need centromeres, but how they form and what they look like is less so. Recent reports extend our understanding of chaperones involved in centromere formation. And other accounts of half-sized, right-handed nucleosomes have created an unexpected twist. ...[more]

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