Ontology highlight
ABSTRACT:
SUBMITTER: Hartmann J
PROVIDER: S-EPMC2734099 | biostudies-literature | 2008 Nov-Dec
REPOSITORIES: biostudies-literature
Hartmann John J Garland Theodore T Hannon Robert M RM Kelly Scott A SA Muñoz Gloria G Pomp Daniel D
The Journal of heredity 20080609 6
Prolonged selective breeding of Hsd:ICR mice for high levels of voluntary wheel running has favored an unusual phenotype (mini-muscle [MM]), apparently caused by a single Mendelian recessive allele, in which hindlimb muscle mass is reduced by almost 50%. We recently described the creation and phenotypic characterization of a population suitable for mapping the genomic location of the MM gene. Specifically, we crossed females from a high-runner line fixed for the MM allele with male C57BL/6J. F1 ...[more]