Ontology highlight
ABSTRACT:
SUBMITTER: Luckner SR
PROVIDER: S-EPMC2734888 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Structure (London, England : 1993) 20090701 7
Mycobacteria have a unique cell wall consisting of mycolic acids, very-long-chain lipids that provide protection and allow the bacteria to persist within human macrophages. Inhibition of cell wall biosynthesis is fatal for the organism and a starting point for the discovery and development of novel antibiotics. We determined the crystal structures of KasA, a key enzyme involved in the biosynthesis of long-chain fatty acids, in its apo-form and bound to the natural product inhibitor thiolactomyci ...[more]