Ontology highlight
ABSTRACT:
SUBMITTER: Custar DW
PROVIDER: S-EPMC2735232 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20090901 34
The total synthesis and biological evaluation of neopeltolide and analogs are reported. The key bond-forming step utilizes a Lewis acid-catalyzed intramolecular macrocyclization that installs the tetrahydropyran ring and macrocycle simultaneously. Independent of each other, neither the macrolide nor the oxazole side chain substituents of neopeltolide can inhibit the growth of cancer cell lines. The biological data of the analogs indicate that alterations to either the ester side chain or the ste ...[more]