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Structural basis for exon recognition by a group II intron.

ABSTRACT: Free group II introns are infectious retroelements that can bind and insert themselves into RNA and DNA molecules via reverse splicing. Here we report the 3.4-A crystal structure of a complex between an oligonucleotide target substrate and a group IIC intron, as well as the refined free intron structure. The structure of the complex reveals the conformation of motifs involved in exon recognition by group II introns.

SUBMITTER: Toor N

PROVIDER: S-EPMC2735234 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature

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Structural basis for exon recognition by a group II intron.

Toor Navtej N Rajashankar Kanagalaghatta K Keating Kevin S KS Pyle Anna Marie AM

Nature structural & molecular biology 20081026 11

Free group II introns are infectious retroelements that can bind and insert themselves into RNA and DNA molecules via reverse splicing. Here we report the 3.4-A crystal structure of a complex between an oligonucleotide target substrate and a group IIC intron, as well as the refined free intron structure. The structure of the complex reveals the conformation of motifs involved in exon recognition by group II introns. ...[more]

PMID: 18953333

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