Ontology highlight
ABSTRACT:
SUBMITTER: Park B
PROVIDER: S-EPMC2735466 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Nature immunology 20081019 12
Toll-like receptors (TLRs) activate the innate immune system in response to pathogens. Here we show that TLR9 proteolytic cleavage is a prerequisite for TLR9 signaling. Inhibition of lysosomal proteolysis rendered TLR9 inactive. The carboxy-terminal fragment of TLR9 thus generated included a portion of the TLR9 ectodomain, as well as the transmembrane and cytoplasmic domains. This cleavage fragment bound to the TLR9 ligand CpG DNA and, when expressed in Tlr9(-/-) dendritic cells, restored CpG DN ...[more]